1. There's no way it costs $10,000 to $20,000 a gram at scale. Those 3 chemical supply companies specialize in having a very large catalog of small quantities of chemicals for biologists to test in their experiments. (I have personally ordered from 2 out of those 3 for my research.) The price they charge per gram is not competitive at all.
Of course, if you want to buy 100g of allopregnanolone at $10,000/g, I'd be happy to make it for you.
2. For point 7 ( why not just give people progesterone?) In my opinion it seems like it should work, since it's the relevant precursor (and the fact that progesterone levels decline after birth is what's driving the decline of allopregnanolone). I'm interested in seeing your follow-up.
Some quick comments (might post more later):
Edit: the long version about progesterone became long enough to be its own blog post, which is now here: https://denovo.substack.com/p/progesterone-explained
1. There's no way it costs $10,000 to $20,000 a gram at scale. Those 3 chemical supply companies specialize in having a very large catalog of small quantities of chemicals for biologists to test in their experiments. (I have personally ordered from 2 out of those 3 for my research.) The price they charge per gram is not competitive at all.
Of course, if you want to buy 100g of allopregnanolone at $10,000/g, I'd be happy to make it for you.
2. For point 7 ( why not just give people progesterone?) In my opinion it seems like it should work, since it's the relevant precursor (and the fact that progesterone levels decline after birth is what's driving the decline of allopregnanolone). I'm interested in seeing your follow-up.