Hey... I love you Steve and agree with most everything here.... except your sentence: "In plain English, in test tube experiments, part of the gene sequence from the vaccine is getting incorporated into our DNA which is extremely troubling to everyone because it is never supposed to happen."
So. Taking the mRNA to DNA is one step, we call that reverse transcription, and that is done by a reverse transcriptase enzyme. Yes, that happens, as shown in the paper. (from https://www.mdpi.com/1467-3045/44/3/73/htm). But there are more steps than just that to have the (now) spike DNA become part of the genome of the host cell. That takes a step called DNA TRANSPOSITION, and requires other enzymes to achieve it. At minimum it takes an enzyme to cut the host DNA (a nuclease), and then an enzyme to anneal or join the spike DNA nucleotides in the host DNA genome. (A lot more to read here about DNA Transposition, if interested. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/dna-transposition).
I just want to be really clear. We are not seeing (yet) the actual transposition of spike DNA into the host/human genome. This is what the CIMB paper specifically has to say in the Discussion section about Transposition: "...this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome and affect the integrity of genomic DNA, which may potentially mediate genotoxic side effects. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity..."
So having spike DNA in a human DNA genome has not been shown/proven. YET. (Do I think it will be show/proven? Probably it will. Nothing surprises me anymore.)
Hey... I love you Steve and agree with most everything here.... except your sentence: "In plain English, in test tube experiments, part of the gene sequence from the vaccine is getting incorporated into our DNA which is extremely troubling to everyone because it is never supposed to happen."
So. Taking the mRNA to DNA is one step, we call that reverse transcription, and that is done by a reverse transcriptase enzyme. Yes, that happens, as shown in the paper. (from https://www.mdpi.com/1467-3045/44/3/73/htm). But there are more steps than just that to have the (now) spike DNA become part of the genome of the host cell. That takes a step called DNA TRANSPOSITION, and requires other enzymes to achieve it. At minimum it takes an enzyme to cut the host DNA (a nuclease), and then an enzyme to anneal or join the spike DNA nucleotides in the host DNA genome. (A lot more to read here about DNA Transposition, if interested. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/dna-transposition).
I just want to be really clear. We are not seeing (yet) the actual transposition of spike DNA into the host/human genome. This is what the CIMB paper specifically has to say in the Discussion section about Transposition: "...this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome and affect the integrity of genomic DNA, which may potentially mediate genotoxic side effects. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity..."
So having spike DNA in a human DNA genome has not been shown/proven. YET. (Do I think it will be show/proven? Probably it will. Nothing surprises me anymore.)