A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection
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Solid phase synthesis of novel asymmetric hydrophilic head cholesterol-based cationic lipids with potential DNA delivery
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2008, Bioorganic and Medicinal ChemistryWhole animal in vivo imaging after transient, nonviral gene delivery to the rat central nervous system
2008, Molecular TherapyCitation Excerpt :Lipids and formulation of lipid:nucleic acid complexes (lipoplexes). After in vitro comparisons with several commercially available lipids, the cationic lipid that performed best was MLRI.23,24 This lipid was then used for further transfections in vitro and in vivo.
Synthesis of carbamate-linked lipids for gene delivery
2005, Bioorganic and Medicinal Chemistry LettersEnhancing direct in vivo transfection with nuclease inhibitors and pulsed electrical fields
2002, Methods in EnzymologyNonviral gene delivery to the lateral ventricles in rat brain: Initial evidence for widespread distribution and expression in the central nervous system
2001, Molecular TherapyCitation Excerpt :We refer to our optimized, controlled incubation of DNA and cationic lipid which leads to the self-assembly of these nucleic acid/cationic lipid complexes as “formulation.” In vitro transfections were optimized using novel cationic lipids developed by Nantz et al. (8–10). DNA dose and cationic lipid to DNA ratio was systematically varied in a series of transfections to arrive at our optimized formulation.
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