How Fevers REALLY Work

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2021Jul 2

Fevers are one of our best weapons against infections, but they don't work like you might think. We'd like to give a big thank you to Sharon Evans from the Roswell Park Comprehensive Cancer Center for sharing her expertise for this video! LEARN MORE ************** To learn more about this topic, start your googling with these keywords: Fever: a rise in body temperature, usually caused by infection Heat shock proteins (HSP): a family of proteins that are produced by cells in response to exposure to stressful conditions Neutrophils: white blood cells that play an important role in inflammation and are early responders to pathogens. T cells: major components of the adaptive immune system whose roles include regulating the immune response to pathogens. SUPPORT MINUTEEARTH ************************** If you like what we do, you can help us!:

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CREDITS ********* Kate Yoshida | Script Writer, Narrator and Director Arcadi Garcia i Rius (@garirius) | Illustration, Video Editing and Animation Nathaniel Schroeder | Music MinuteEarth is produced by Neptune Studios LLC https://neptunestudios.info OUR STAFF ************ Sarah Berman • Arcadi Garcia i Rius David Goldenberg • Julián Gustavo Gómez Melissa Hayes • Alex Reich • Henry Reich • Peter Reich Ever Salazar • Leonardo Souza • Kate Yoshida OUR LINKS ************ Youtube | / minuteearth TikTok | / minuteearth Twitter | / minuteearth Instagram | / minute_earth Facebook | / minuteearth Website | https://minuteearth.com Apple Podcasts| https://podcasts.apple.com/us/podcast... REFERENCES ************** Appenheimer, M.M. & Evans, S.S. (2018) Temperature and adaptive immunity. Handbook of Clinical Neurology 156: 397–415. https://linkinghub.elsevier.com/retri... Casadevall, A. (2016) Thermal Restriction as an Antimicrobial Function of Fever. PLoS Pathog 12(5): e1005577. https://journals.plos.org/plospathoge... ChangDong L. et al. (2019). Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity 50(1):137-151. https://www.cell.com/immunity/fulltex... Evans, S.S. et al. (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology 15(6): 335+. https://www.ncbi.nlm.nih.gov/pmc/arti... Hasday, J.D., Thompson, C., Singh, I.S. (2014) Fever, immunity, and molecular adaptations. Comprehensive Physiology 4:109–48. https://onlinelibrary.wiley.com/doi/1... Hasday, J.D. & Singh, I.S. (2000) Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones 5:471–480. https://www.ncbi.nlm.nih.gov/pmc/arti... Javid, B., MacAry, P.A. & Lehner, P.J. (2007) Structure and function: heat shock proteins and adaptive immunity. Journal of Immunology 179:2035–2040. https://www.jimmunol.org/content/179/... Mackowiak, P. A.: Direct effects of hyperthermia on pathogenic microorganisms: teleological implications with regard to fever. Reviews of Infectious Diseases 1981, 3: 508–518. https://academic.oup.com/cid/article-...